Microsoft best practice states that you should match your sequencing platform to your target platform. App-V has always given us an extremely well working platform to avoid that and still does. However, we have a game changer; Extension Points
What are extension points? More integration into the operating system to allow users to use their virtual applications in a manner they expect that it should simply work.
Did you just pop-in a music CD (not really ?) and had the default media player virtualized?
In App-V 4.X that would cause an issue due to the fact that the operating system had no awareness that you had a media player. Autoplay was not a supported extension point within App-V 4.
As you can see there are several possible choices in the above list on what todo when an Audio CD is inserted. If the application is virtualized – in an App-V 4.X environment it would not be visible in the above list.
App-V 5 changed the game and extended the list to support this scenario and much more. However, there is a new found reason of actually doing what Microsoft has been telling us todo all along.
Your sequencing platform should match your target platform.
For Windows 7 64-bit, you should sequence on Windows 7 64-bit.
In App-V 5 this is even more valid as several extension points are not following along if you attempt to sequence on a 32-bit platform and deploy to a 64-bit platform.